Medical cannabis has garnered attention as an alternative treatment for chronic pain, a condition affecting millions globally. Its efficacy is attributed to its interaction with the body's endocannabinoid system (ECS), crucial for modulating pain, inflammation, and immune functions. With medical cannabis available in Portugal and the UK, understanding its potential for chronic pain management is increasingly relevant.

Mechanism of Action

The ECS includes cannabinoid receptors (CB1 and CB2), endogenous ligands (endocannabinoids), and enzymes for synthesizing and degrading endocannabinoids. Cannabis-derived cannabinoids, like THC and CBD, mimic endocannabinoids, modulating pain perception and inflammation.

• THC binds to CB1 receptors in the brain and central nervous system, altering pain perception and offering analgesic effects.
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• CBD indirectly influences the ECS and other signaling systems, reducing inflammation and neuropathic pain without psychoactive effects (Russo, 2008; Xiong et al., 2012).

Clinical Evidence

Recent studies and systematic reviews highlight medical cannabis' efficacy in treating various types of chronic pain:

• A systematic review by Whiting et al. (2015) found moderate-quality evidence supporting cannabinoids for chronic neuropathic or cancer pain treatment.
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• Haroutounian et al. (2016) noted significant pain relief in chronic neuropathic pain patients using cannabis.
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• Safakish et al. (2020) observed that medical cannabis treatment was associated with improvements in pain severity and interference, maintained over 12 months, and significant decreases in opioid medication use among chronic pain patients.

Considerations and Limitations

While promising, medical cannabis use requires careful consideration of potential side effects and challenges:

• Side Effects: These may include cognitive impairment, dizziness, and dependency. Medical guidance helps mitigate these risks.
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• Variability: Differences in strains, dosages, and administration methods complicate treatment standardization.
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• Accessibility: Legal restrictions can impact availability. In Portugal, medical cannabis is accessible with a prescription, while the UK is advancing its regulatory framework to enhance patient access.

FAQs

How does medical cannabis help manage chronic pain?
Medical cannabis interacts with the endocannabinoid system, modulating pain perception and reducing inflammation, offering an alternative treatment for chronic pain.

Are there any risks associated with using medical cannabis for chronic pain?
Potential side effects include cognitive impairment, dizziness, and dependency. It's important to use medical cannabis under medical supervision.

Can medical cannabis reduce the use of opioid painkillers?
Yes, studies have shown that medical cannabis use is associated with decreased opioid use in chronic pain patients.

Is medical cannabis legal for chronic pain management?
The legality of medical cannabis varies by jurisdiction. In places where it's legal, it can be prescribed for chronic pain under certain conditions.

Conclusion

Medical cannabis offers a valuable alternative for chronic pain management, targeting the body's natural pain modulation systems. With its growing availability in Portugal and the UK, patients now have new opportunities to explore its therapeutic potential. However safe and effective use requires careful consideration of dosage, administration methods and professional guidance.

Take the next step toward managing chronic pain with expert support. Download the pH7 Patients App to connect with qualified doctors specializing in medical cannabis. Receive personalized consultations, legitimate prescriptions, and tailored treatment plans to improve your quality of life.

Bibliography

Abrams, D. I. (2007). "An overview of the clinical use of cannabinoids in oncology." Journal of Palliative Medicine.

Blessing, E. M., et al. (2015). "Cannabidiol as a potential treatment for anxiety disorders." Neurotherapeutics.

Boehnke, K. F., Litinas, E., & Clauw, D. J. (2016). "Medical cannabis use is associated with decreased opiate medication use in a retrospective cross-sectional survey of patients with chronic pain." The Journal of Pain.

Devinsky, O., et al. (2017). "Trial of cannabidiol for drug-resistant seizures in the Dravet syndrome." The New England Journal of Medicine.

Haroutounian, S., et al. (2016). "The effect of medicinal cannabis on pain and quality-of-life outcomes in chronic pain: A prospective open-label study." The Clinical Journal of Pain.

Hill, K. P. (2015). "Medical marijuana for treatment of chronic pain and other medical and psychiatric problems: A clinical review." JAMA.

Naftali, T., et al. (2013). "Treatment of Crohn's disease with cannabis: An observational study." Israel Medical Association Journal.

Russo, E. B. (2008). "Cannabinoids in the management of difficult to treat pain." Therapeutics and Clinical Risk Management.

Safakish, R., et al. (2020). "Medical Cannabis for the Management of Pain and Quality of Life in Chronic Pain Patients: A Prospective Observational Study." Pain Medicine.

Whiting, P. F., et al. (2015). "Cannabinoids for medical use: A systematic review and meta-analysis." JAMA.

Xiong, W., et al. (2012). "Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors." Journal of Experimental Medicine.

Disclaimer

The content provided in this article is for informational purposes only and should not be considered medical advice. Always consult a qualified healthcare professional before using cannabis for medicinal purposes. For personalized medical guidance, consult a licensed healthcare provider through the pH7 Patients app. pH7 is a technology platform connecting patients with doctors specializing in medical cannabis, providing legitimate medical consultations and access to digital prescriptions.

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